Why the recent surge in interest in methylene blue?

The recent surge in interest around methylene blue is largely due to its potential cognitive and neuroprotective benefits, especially within the biohacking, longevity, and nootropic communities. Here are the main reasons it’s gaining attention:

 

 

 

1. Mitochondrial Function and Energy Boost

 

• Methylene blue has been shown to enhance mitochondrial respiration—the process that cells use to produce energy (ATP).
• Improved mitochondrial efficiency is linked to better brain function, mental clarity, and energy levels.

 

 

2. Neuroprotection and Anti-Aging Potential

• Some research suggests it may reduce the formation of tau proteins and amyloid plaques—hallmarks of Alzheimer’s disease.
• It may also reduce oxidative stress and protect neurons from degeneration, making it attractive in the context of brain aging.

 

 

 

3. Cognitive Enhancement Claims

 

• Users and a few preliminary studies report enhanced memory, mood, and focus when using low doses.
• It’s sometimes included in nootropic stacks aimed at mental performance optimization.

 

4. Psychedelic and Mood Research

• It’s being investigated for psychedelic-assisted therapy (e.g., enhancing visual clarity and emotional processing), though this use is more experimental.
• Methylene blue is also a monoamine oxidase inhibitor (MAOI), so it interacts with neurotransmitters like serotonin and dopamine

 

 

 

5. Biohacking Trends & Social Media

• Influencers and biohackers have helped popularize methylene blue by showcasing its supposed effects, sometimes even using it sublingually or intravenously (which is not medically advised without supervision).
• Its vivid blue color and visual appeal in social media posts add to the intrigue.

 

 

Despite the buzz, there are still risks—especially if taken at high doses or combined with certain medications (e.g., SSRIs or antidepressants). Research is promising but not conclusive.